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Dah-eun (Chloe) Chung, Ph.D.

Postdoctoral Associate at 
Dr. Huda Zoghbi’s lab

Baylor College of Medicine

Interests

  • Neurodegeneration

  • Alzheimer’s disease

  • Tau & tauopathies

  • Molecular neuroscience

  • Regional brain vulnerability

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About Chloe

A highly motivated neuroscientist with expertise in molecular biology and strong interpersonal skills whose long-term research goal is to lead a rigorous, multi-faceted research program as an independent investigator to (1) investigate molecular players that can critically drive or suppress pathological protein aggregation and neurodegeneration in Alzheimer’s disease (AD) and other neurodegenerative diseases, (2) develop therapeutic strategies to effectively reverse and/or prevent pathological changes of tau in the brain, and (3) elucidate splicing regulators and biological roles of an understudied, pathology-resisting big tau isoform.

Current Position: Postdoctoral Associate
Advisor: Huda Y. Zoghbi, M.D.

  • Leading the characterization of properties and functions of an atypical “big tau” isoform that resists pathological changes.

  • Investigating novel regulators that can critically modulate the expression level and post-translational modifications of tau.

Education

Education

2019-Present

Postdoctoral Associate

Advisor: Huda Y. Zoghbi, M.D.

Baylor College of Medicine (BCM)

2013-2019

Ph.D. in Neuroscience

Advisor: Leonard Petrucelli, Ph.D.

Committee: Drs. Dennis W. Dickson,

Jungsu Kim, Pamela J. McLean, John D. Fryer

Mayo Clinic Graduate School of

Biomedical Sciences (MCGSBS)

2008-2012

Washington University in St. Louis

B.A. in Biochemistry

Minor in Philosophy-Neuroscience-Psychology

Publications

Publications

1. Chung DC, Deng X, Yalamanchili H, Revelli JP, Han A, Tadros B, Richman R, Dias M, Naini FA, Boeynaems S, Hyman BT, and Zoghbi HY. (2024) “The big tau splice isoform resists Alzheimer’s-related pathological changes.” bioRxiv. (Manuscript In Revision.)

·   Featured in: AlzForum, The Transmitter, GWAS Stories

2. Tadros B, Kim J, Xhako E, Chung DC, Li Y, Kim Y, Liang YH, Jung SY, Zoghbi HY. “LMO7 modulates tau levels by regulating CHIP-BAG5 interplay: Novel insights into tauopathy mechanisms.” In preparation.

3. Kim J, Tadros B, Liang YH, Kim Y, Lasagna-Reeves C, Sonn JY, Chung DC, Hyman BT, Holtzman DM, Zoghbi HY. (2024) “TYK2 regulates tau levels, phosphorylation, and aggregation in tauopathy model mice”. Nature Neuroscience 27(12): 2417-2429.    

  

4. Chung DC, Roemer S, Petrucelli L, and Dickson DW. (2021) “Cellular and pathological heterogeneity of primary tauopathies.” Molecular Neurodegeneration 16(1): 57.

5. Chung DC, Carlomagno Y, Cook CN, Jansen-West KR, Daughrity L, Lewis-Tuffin LJ, Castanedes-Casey M, DeTure M, Dickson DW*, and Petrucelli L*. (2019) “Tau Exhibits Unique Seeding Properties in Globular Glial Tauopathy.” Acta Neuropathologica Communications 7(1): 36. (* Co-corresponding authors.)

6. Carlomagno Y, Chung DC, Yue M, Kurti A, Avendaño NM, Castanedes-Casey M, Ross KM, Jansen-West K, Daughrity L, Tong J, Phillips V, Rademakers R, DeTure M, Fryer JD, Dickson DW, Petrucelli L, Cook CN. (2019) “Enhanced phosphorylation of T153 in soluble tau is a defining biochemical feature of the A152T tau risk variant.” Acta Neuropathologica Communications 7(1): 10.

7. Chung DC*, Stankowski JN*, and Petrucelli L. (2017) “Neurobiology of FTD: Animal and Human Studies.” Charney & Nestler's Neurobiology of Mental Illness 5th edition. Charney DS, Nestler EJ, Sklar P, Buxbaum JD. Eds. (* Equal contribution.)

8. Carlomagno Y, Chung DC, Yue M, Castanedes-Casey M, Madden BJ, Dunmore J, Tong J, DeTure M, Dickson DW, Petrucelli L, and Cook C. (2017) “An acetylation-phosphorylation switch that regulates tau aggregation propensity and function.” Journal of Biological Chemistry 292(37): 15277-15286.

9. Kim J, Yoon H, Chung DE, Brown JL, Belmonte KC, and Kim J. (2015) “miR-186 is decreased in aged brain and suppresses BACE1 expression.” Journal of Neurochemistry 137(3): 436-45.

Fundings & Fellowships

[2023-2025]

[2021-2022]

[2013-2015]

[2011]

Alzheimer's Disease Research Postdoctoral Fellowship

Center for Alzheimer’s and Neurodegenerative Diseases (CAND) Scholar

Dean’s Fellowship

Summer Undergraduate Research Fellowship

BrightFocus Foundation, PI

BCM

MCGSBS

Howard Hughes Medical Institute

Fundings & Fellowships

Honors & Awards

[2023]

[2022]

[2022]

[2017]

[2017]

[2013]

Dean’s Award of Excellence

Research Award

Excellence in Research Award

Predoctoral Travel Award

Best Poster Award

Conference Scholarship

School of Biomedical Sciences, BCM

KSEA West Gulf Coast Regional Conference

KSEA Texas Biomedical Trainee Symposium

MCGSBS

MCGSBS Annual Student Research Symposium

Mayo Clinic Center for Individualized Medicine

Presentations

Invited Talks

[2024]

[2024]

[2023]

[2022]

[2022]

[2022]

[2020]

Weill Cornell Medicine Emerging Leaders in Neuroscience Seminar Korea Advanced Institute of Science & Technology Symposium Neurological Research Institute Seminar Series

Korea Brain Research Institute Seminar

Cross-Disciplinary Alzheimer’s Disease Research Symposium Neurological Research Institute Seminar Series

Alzheimer’s Disease Trainee Happy Hour Webinar Series

New York, NY USA

Daejeon, South Korea

Houston, TX, USA

Daegu, South Korea

Houston, TX, USA

Houston, TX, USA

Virtual

Selected Talks

[2024]

[2024]

[2023]

[2022]

[2022]

[2022]

Symposium for Postdoctoral Initiatives in Neuroscience Excellence Biennial Meeting of Int’l Society for Molecular Neurodegeneration Charleston Conference on Alzheimer’s Disease
Annual Meeting of Society for Neuroscience

Alzheimer’s Association International Conference 06/2022 KSEA Texas Biomedical Trainee Symposium

Philadelphia, PA, USA

Seoul, South Korea

Charleston, SC, USA

San Diego, CA, USA

San Diego, CA, USA

Houston, TX, USA

Poster Presentation

[2024]

[2024]

[2023]

[2023]

[2023]

[2022]

[2022]

[2018]

[2017]

[2017]

[2015]

[2014]

Greater Houston Area AD Research Symposium

Annual Meeting of Society for Neuroscience

HHMI Science Meeting
KSEA West Gulf Coast Regional Conference

Keystone Symposium on Neurodegeneration

BCM Molecular & Human Genetics Retreat

Tau Global Conference

Keystone Symposium on Neurodegeneration
Annual Meeting of Society for Neuroscience
Mayo Graduate School Research Symposium
National Korean-American Young Generation Conference

Mayo Graduate School Research Symposium

Houston, TX, USA

Chicago, IL, USA

Chevy Chase, MD, USA

Houston, TX, USA

Whistler, BC, Canada

Galveston, TX, USA
Virtual

Keystone, CO, USA

Washington D.C., USA

Rochester, MN, USA

Orlando, FL, USA

Rochester, MN, USA

Outreach

Outreach & Other Service

[2024]

[2023-2024]

[2023-2024]

[2023]

[2022-2023]

[2022, 2025]

[2022]

[2020]

[2020]

[2019-2022]

[2019]

[2019-Present]

[2016-2019]

[2015-2016]

[2014-2015]

Speaker at the KSEA Webinar Series

Organizer for the BCM Seminars for Postdocs Advancing Inclusion (SPAI)

Judge at the Science & Engineering Fair Houston (SEFH)
Panelist at the KSEA Young Generation Forum
Speaker at the Rice University Alzheimer’s Buddies Symposium
Judge at the Baylor College of Medicine Graduate Student Symposium

Judge at the Annual Biomedical Research Conference for Minoritized Students (ABRCMS)
Host of the Alzheimer’s Disease Trainee Happy Hour Webinar Series
Moderator for the Open Box Science Online Symposium
Writer for BrainPost: https://www.brainpost.co/about-brainpost
Guest writer for eNeuro Blog: https://blog.eneuro.org/
Ad-hoc peer-reviewer for Molecular Neurodegeneration, Science Advances, etc.

Board member at the Mayo Clinic Women in Science and Engineering Research (WiSER)
Representative for the Neuroscience PhD Program at the Mayo Graduate School Association

Representative for the Florida Campus at the Mayo Graduate School Association

Contact

Department of Molecular & Human Genetics,

Baylor College of Medicine

Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital

daheunc@bcm.edu

+1-713-798-6558

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